You are most welcome to a knowledge-sharing seminar presented by Assoc. Prof. Thanh Duc Mai at University Paris-Saclay. With a friendly atmosphere, you will have a great chance to discuss and communicate with this scientist for any potential collaborations or research experience.

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Title:

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New analytical concepts and purpose-made instrumentation for pharmaceutical and diagnostic applications

 

Abstract: 

Compared to commercial and costly instruments that may not be adapted to particular operations and / or accessible to modestly-equipped laboratories, purpose-made instrumentation offers many advantageous features (low cost, transportable configurations, flexibility). At the same time, purpose-made devices allow combination of on-line sample treatment and enrichment prior to target analyte separations, which is not readily possible when using commercial setups.

In the first part of the presentation, we report on the development and application of low-cost purpose-made capillary electrophoresis (CE) systems (see Fig. 1) for drug quality control and therapeutic monitoring. The instrument was designed according to the feedbacks of users on our previous prototypes over 10 years.

 The second part is dedicated to the development of a novel system named Lab-in-Droplet, in which each sample processing step can be realized in a microfluidic droplet that serves as a distinct micro-reactor (see Fig. 2). A complex sample treatment protocol that has been feasible so far only in batchwise mode can now be converted into a novel microfluidic version. For inaugural application of Lab-in-Droplet, the platform was applied for mapping N-linked glycans released from human sera, serving for diagnostic screening of congenital disorders of glycosylation.

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Fig. 1. Purpose-made CE instrument

 

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Fig. 2: Lab-in-Droplet system

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Biography:

 

Dr. Thanh Duc MAI is an associate professor in analytical chemistry at the Faculty of Pharmacy of U. Paris Saclay, France. He carries out his research at the Institut Galien Paris-Saclay (IGPS, UMR 8612 CNRS). His current research activities focus on development of novel electrokinetic and microfluidic approaches for biomolecule preconcentration and separation, conception of purpose-made capillary electrophoresis instrumentation, magneto-immunoassays and lab-on-droplet. His research is towards sensitive and selective detection of protein / peptide based biomarkers in biological matrices.

Between 2015-2019, he was co-founder and scientific advisor of the StartUp EcyTech (Switzerland) to develop compact and inexpensive instruments for water analysis, food control and clinical screening. After his doctoral study in analytical chemistry (design and development of analytical instrumentation) at the University of Basel (Switzerland) in 2011, he continued his post-doctoral research in various institutions in France. He has developed different innovative instrumental designs for analytical chemistry, notably the multi-dimension separation system (ANR PRC grant), the "DropLab" (ANR JCJC grant, which combines sample processing in microfluidic droplets and digital separation), the "magneto-CE" (CNRS Instrumentation grant, which exploits the power of immunoassay on magnetic beads with capillary electrophoresis) and the Lego-CE (modular instrument inspired by Lego toys). With the support of Paris-Saclay University, he recently set up actions aimed at leading collaborative research projects involving the use of capillary electrophoresis and microfluidics in Vietnam, with the participation of 5 French companies in these areas since 2019.

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Some recent publications

[1] https://doi.org/10.1016/j.aca.2023.341141

[2] https://doi.org/10.1016/j.aca.2022.340150

[3] https://doi.org/10.1016/j.talanta.2022.123625

[4] https://doi.org/10.1002/elps.202000163

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Time: 13:00 CET (18:00 Vietnam), 8th September, 2023

Zoom link:  https://lu-se.zoom.us/j/6579302725

Chairmain: Assoc. Prof. Minh Huong Ha, France